Important Safety Information
INDICATIONS AND USAGE
What is VIMOVO® (naproxen and esomeprazole magnesium)?
VIMOVO contains two medicines: naproxen, a nonsteroidal anti-inflammatory drug (NSAID) and esomeprazole magnesium, a proton pump inhibitor (PPI). VIMOVO is used to relieve signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis and to decrease the risk of developing stomach (gastric) ulcers in people who are at risk of developing gastric ulcers with NSAIDs. You should not take a naproxen tablet and an esomeprazole magnesium tablet together instead of taking VIMOVO, because they will not work the same way.
IMPORTANT SAFETY INFORMATION
VIMOVO can cause serious side effects. Stop taking VIMOVO and call your doctor or go to your emergency department right away if you get:
- Difficulty breathing, swelling of the face or throat. These could be signs of a serious allergic reaction.
- Chest pain, shortness of breath, weakness in one part or side of your body, or slurring of speech. These could be signs of a serious blood clotting event.
- Upper stomach pain, upset stomach, black, tarry stools, or vomiting of blood. These could be signs of an esophagus, stomach, or intestinal ulcer, bleed, or tear. Note: if you are also taking low-dose aspirin, you are at increased risk for esophagus, stomach, or intestinal bleeding.
- Nausea, more tired or weaker than usual, itching, yellowing of the skin or eyes, right upper abdomen tenderness, and “flu-like” symptoms. These could be signs of a liver problem.
- Shortness of breath, unexplained weight gain, or swelling of the arms, legs, hands, or feet. These could be signs of a serious heart problem.
- Diarrhea that does not improve. This could be a sign of an infection called Clostridium difficile infection.
- Any type of rash. This could be a sign of a serious skin reaction.
- New or worsening joint pain or a rash on your cheeks or arms that gets worse in the sun. These could be signs of certain types of lupus erythematosus.
- Decreased volume of urine or blood in urine. These could be signs of a kidney problem.
These are not all of the possible side effects of VIMOVO. Please talk to your doctor if you experience any symptoms that bother you or that do not go away.
What is the most important information I should know about VIMOVO?
- NSAIDs, a component of VIMOVO, cause an increased risk of serious blood clotting events, including heart attack and stroke, which can kill you. This risk may occur early in treatment and may increase with longer use. To minimize the potential for increased risk of serious heart events while being treated with an NSAID, use the lowest effective dose for the shortest duration possible.
- NSAIDs, a component of VIMOVO, cause an increased risk of serious esophagus, stomach, and intestine events including bleeding, ulcers, and tears, which can kill you. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a history of ulcer disease or stomach or intestine bleeding are at greater risk for serious esophagus, stomach, and intestine events.
Who should not use VIMOVO?
- DO NOT USE VIMOVO if you
- are in the hospital for a certain heart surgery called coronary artery bypass graft surgery.
- know you are allergic to naproxen, esomeprazole magnesium, substituted benzimidazoles, or to any ingredient of the drug product, including omeprazole.
- have experienced asthma, hives, or allergic-type reactions after taking aspirin or other NSAIDs. Serious allergic reactions to NSAIDs, including death, have been reported in such patients.
How should I take VIMOVO?
Take VIMOVO exactly as your health care provider tells you to take it. Do not change your dose or stop VIMOVO without first talking to your health care provider. Take VIMOVO at least 30 minutes before a meal. Swallow VIMOVO tablets whole with liquid. Do not split, chew, crush, or dissolve the VIMOVO tablet. If you forget to take a dose of VIMOVO, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take 2 doses at one time to make up for a missed dose.
What are the possible side effects of VIMOVO?
The most common side effects of VIMOVO are inflammation of the lining of the stomach and diarrhea.
What other medications might interact with VIMOVO?
Avoid using VIMOVO while taking other naproxen-containing products or other non-aspirin NSAIDs, clopidogrel, St. John’s Wort, rifampin, or methotrexate. NSAIDs may be present in over-the-counter medications for treatment of colds, fever, or insomnia; refer to the label of over-the-counter medications you are taking or ask your pharmacist. Do not use VIMOVO and low-dose aspirin until you talk to your health care provider. Tell your doctor about all of the medicines you take as some medicines can react with NSAIDs and cause serious side effects.
What should I tell my healthcare provider?
Before starting VIMOVO, tell your health care provider if you have a history of ulcer disease or esophagus, stomach, or intestine bleeding, liver or kidney problems, high blood pressure, asthma, low magnesium levels, ulcerative colitis or Crohn’s disease, or are pregnant, trying to become pregnant, or breast feeding. Talk to your doctor about the risk of bone fractures or developing low magnesium or vitamin B-12 levels if you take VIMOVO for a long period of time. Also tell your doctor about all of the medicines you take, including prescription or over-the-counter medicines, vitamins, or herbal supplements. Do not start taking new medicines without talking to your health care provider first.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or [email protected].
The risk information provided here is not comprehensive. To learn more, talk about VIMOVO with your health care provider or pharmacist. The FDA-approved product labeling can be found at www.VIMOVO.com or 1‑866‑479‑6742.