• OA/RA Pain Relief


    VIMOVO combines relief from OA/RA pain and inflammation with reduced risk of developing stomach ulcers in one tablet

    Learn about VIMOVO
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  • VIMOVO Patient Brochure







What is the most important information I should know about VIMOVO?

VIMOVO can cause serious side effects. Stop taking VIMOVO and call your doctor or go to your emergency department right away if you get:

These are not all of the possible side effects of VIMOVO. Please talk to your doctor if you experience any symptoms that bother you or that do not go away. If you take too much VIMOVO, call your poison control center at 1-800-222-1222.



What is VIMOVO® (naproxen and esomeprazole magnesium)?

VIMOVO contains two medicines: naproxen, a nonsteroidal anti-inflammatory drug (NSAID) and esomeprazole magnesium, a proton pump inhibitor (PPI). VIMOVO is a prescription medicine used in adults and adolescents, 12 years of age and older who weigh at least 84 pounds (38 kg), who need to take naproxen for relief of symptoms of arthritis and who also need to decrease the risk of developing stomach ulcers caused by naproxen.

The naproxen in VIMOVO is used for the relief of signs and symptoms of:

The esomeprazole magnesium in VIMOVO is used to decrease the risk of developing stomach ulcers in people who are taking naproxen.

It is not known if VIMOVO is safe and effective in children less than 12 years of age or who weigh less than 84 pounds (38 kg). You should not take a naproxen tablet and an esomeprazole magnesium tablet together instead of taking VIMOVO, because they will not work the same way. Studies in people who take VIMOVO have not extended past 6 months.

Who should not use VIMOVO?


How should I take VIMOVO?

Take VIMOVO exactly as your health care provider tells you to take it. Take VIMOVO at least 30 minutes before a meal. Swallow VIMOVO tablets whole with liquid. Do not split, chew, crush, or dissolve the VIMOVO tablet. If you forget to take a dose of VIMOVO, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take 2 doses at one time to make up for a missed dose.

What are the possible side effects of VIMOVO?

The most common side effects of VIMOVO are inflammation of the lining of the stomach and diarrhea.

What other medications might interact with VIMOVO?

Avoid using VIMOVO while taking other naproxen-containing products or other non-aspirin NSAIDs, clopidogrel, St. John’s Wort, or rifampin. NSAIDs may be present in over-the-counter medications for treatment of colds, fever, or insomnia; refer to the label of over-the-counter medications you are taking or ask your pharmacist. Do not use VIMOVO and low-dose aspirin until you talk to your health care provider. Tell your health care provider about all of the medicines you take as some medicines can react with VIMOVO and cause serious side effects.

What should I tell my health care provider?

Before starting VIMOVO, tell your health care provider if you have a history of ulcer disease or esophagus, stomach, or intestine bleeding, liver or kidney problems, high blood pressure, heart problems, asthma, low magnesium levels, ulcerative colitis or Crohn’s disease, or are pregnant, trying to become pregnant, or breast feeding. Talk to your health care provider about the risk of bone fractures or a certain type of stomach growths or developing low magnesium or vitamin B-12 levels if you take VIMOVO for a long period of time. Also tell your health care provider about all of the medicines you take, including prescription or over-the-counter medicines, vitamins, or herbal supplements. Do not start taking new medicines without talking to your health care provider first.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation@horizonpharma.com.

The risk information provided here is not comprehensive. To learn more, talk about VIMOVO with your health care provider or pharmacist. Click here for Prescribing Information and Medication Guide or call 1-866-479-6742.